Does Ventilatory Time Retain Its Validity in Predicting Neurodevelopmental Outcome at Two Years of Age in High-Risk Congenital Diaphragmatic Hernia Survivors?

Francesca Bevilacqua; Francesco Morini; Antonio Zaccara; Laura Valfrè; Lelia Rotondi Aufiero; Simonetta Gentile; Pietro Bagolan; Lucia Aite

doi:10.1055/s-0036-1586120

American Journal of Perinatology, Table of Contents

Am J Perinatol 2017; 34(03): 248-252
DOI: 10.1055/s-0036-1586120

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Does Ventilatory Time Retain Its Validity in Predicting Neurodevelopmental Outcome at Two Years of Age in High-Risk Congenital Diaphragmatic Hernia Survivors?

Francesca Bevilacqua

¹Unit of Clinical Psychology, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy

,

Francesco Morini

²Department of Neonatal Medicine and Surgery, Bambino Gesù Children's Hospital, Rome, Italy

,

Antonio Zaccara

³Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy

,

Laura Valfrè

²Department of Neonatal Medicine and Surgery, Bambino Gesù Children's Hospital, Rome, Italy

,

Lelia Rotondi Aufiero

⁴Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy

,

Simonetta Gentile

¹Unit of Clinical Psychology, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy

,

Pietro Bagolan

²Department of Neonatal Medicine and Surgery, Bambino Gesù Children's Hospital, Rome, Italy

,

Lucia Aite

¹Unit of Clinical Psychology, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy

› Author Affiliations

Abstract

Objective To evaluate if in high-risk non–extracorporeal membrane oxygenation (ECMO)-treated congenital diaphragmatic hernia (CDH) survivors, ventilatory time (VT) is correlated to and can be used as clinical marker of neurodevelopmental delay at 2 years of age.

Study Design Cohort study was conducted between 2008 and 2012. Mental, motor, and language development were assessed by the Bayley Scales of Infant and Toddler Development III. The correlation between VT and neurodevelopmental outcome (NDO) was analyzed using Pearson's test. Receiver operating characteristic (ROC) analysis was performed to determine the accuracy and best cutoff value of VT to predict the risk of neurodevelopmental delay. Statistical significance was set at p < 0.05.

Results A total of 49 patients form the subject of this study. VT during first admission was inversely correlated with cognitive (r = –0.4116; p = 0.0033), motor (r = –0.4241; p = 0.0024), and language development (r = –0.3564; p = 0.0119). Using ROC curve analysis, VT was a significant predictor for neurodevelopmental delay in the cognitive (area under the curve [AUC]: 0.864, sensitivity: 100; specificity: 66.67; p < 0.0001) and motor (AUC: 0.902; sensitivity: 100; specificity: 73.17; p < 0.0001) scales, but not in the language scale. The best cutoff value for both scales was 9 days.

Conclusion Within a population of high-risk non-ECMO-treated CDH survivors, VT appears to retain its validity as a clinical marker of adverse NDO in cognitive and motor domains.

Keywords

CDH - ventilatory time - neurodevelopmental outcome

Full Text

References

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